Global burden of metabolic diseases: data from Global Burden of Disease 2000-2019. A cosortium of metabolic disease

Abstract Funding Acknowledgements Type of funding sources: None. Background The growing prevalence metabolic diseases is a major concern. We sought to examine the global trends and mortality using estimates from Global Burden Diseases, Injuries Risk Factors Study (GBD) 2019. Methods prevalence, deaths, disability-adjusted life year (DALYs) 2000-2019 were examined for (type 2 diabetes mellitus [T2DM], hypertension, nonalcoholic fatty liver disease [NAFLD]). For risk factors (hyperlipidemia obesity), limited DALYs. Death rates was compared across sex, World Health Organisation regions Socio-demographic Index (SDI) quintiles. Age-standardised death presented per 100,000 population with 95% uncertainty intervals (UI). Findings From 2000 2019, increased all diseases, most pronounced increase in high SDI countries. In mean (95%UI) age-standardised estimated be 15,023 (13,493-16,764) NAFLD, 5,283 (4,864–5,720) T2DM 234 (171-313) hypertension. highest observed obesity (62·59 [39·92-89·13]; males, 66·55 [39·76-97·21]; females. 58·14 [38·53-81·39]), followed by hyperlipidemia (56·51 [41·83-73·62]; 67·33 [50·78-86·43]; females, 46·50 [32·70-62·38]), (18·49 [17·18-19·66], hypertension (15·16 [11·20-16·75]; 14·95 [10·32-16·75]; 15·05 [11·51-17·09]) NAFLD (2·09 [1·61-2·60]; 2·38 [1·82-3·02]; 1·82 [1·41-2·27]). Mortality decreased over time (-154%), (-52%) (-52%), but not obesity. found Eastern Mediterranean, low low-middle Conclusion has risen past two decades regardless SDI. Attention needed address unchanging attributed regional, socioeconomic, sex disparities disease.